Endocrine Abstracts

The aim of this study was to evaluate whether the coexistence of obesity in children with precocious puberty symptoms influences significantly the diagnostic process.Material and methods: We retrospectively analysed a group of 200 children’s records (F/M 164/36) hospitalised because of precocious puberty suspicion. The analysis evaluated the nutritional status based on BMI percentile level, compatibility between the bone age and the chronological ag...

With the increasing prevalence of obesity in children, there is a growing number of its comorbidities as nonalcoholic fatty liver disease (NAFLD).The aim of this study was to evaluate the prevalence of NAFLD in a group of obese patients and to identify additional risk factors for NAFLD development in the examined population.Materials and methods: We examined 88 obese children (41 boys) mean age 14.4 (±2.6) hospitalized in our ...

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...

Introduction: Subclinical hypothyroidism (sHT) is defined as elevated level of TSH with normal levels of thyroid hormone. In obese children there is a high frequency of this disturbance. However, the influence of sHT on therapy success and an appearance of metabolic complications in childhood obesity is unclear. Furthermore, the supplementation L-thyroxin (L-T4) in this case seems to be very controversial.Aim: The...

Type II germ cell tumors are predictable complications in patients with disorder of sex development (DSD) and with Y chromosome present. The risk of tumor development varies significantly between subsets of DSD and in some cases early gonadectomy is perceived as overtreatment.The aim of the study was to analyze the gonadal tumor incidence in 45,X/46,XY and 46,XY patients who were reared as female and managed at single institution between 1997 and 2013.</...